Smaller doses of drug administered via the inhalation route are effective because there is no first-pass effect in the GI tract.

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Smaller doses of drugs administered via the inhalation route are effective because they bypass the first-pass effect in the gastrointestinal (GI) tract, where some of the drug may be metabolized and excreted before it reaches the bloodstream. Inhalation drugs are absorbed directly into the lungs and quickly reach the systemic circulation, allowing for lower doses to be effective.

Smaller Doses of Drug Administered Via the Inhalation Route Are