The constriction of arterioles causes an increase in afterload and systemic vascular resistance.

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Arterioles are the smallest blood vessels that regulate blood flow to capillaries. Their constriction leads to an increase in afterload, which is the resistance encountered by the left ventricle while ejecting blood during systole. This, in turn, increases the systemic vascular resistance (SVR), which is the total resistance offered by all the blood vessels in the systemic circulation. Higher SVR increases the workload of the heart and impairs its ability to pump blood effectively, leading to hypertension, left ventricular hypertrophy, and heart failure over time.

The Constriction of Arterioles Causes an Increase in Afterload and Systemic