The first-line empiric antibiotic choice for treatment of community-acquired pneumonia is penicillin.

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The first-line empiric antibiotic choice for treatment of community-acquired pneumonia varies based on the severity of the illness and patient-specific factors. Commonly used antibiotics include macrolides (e.g. azithromycin), fluoroquinolones (e.g. levofloxacin), and cephalosporins (e.g. ceftriaxone). Penicillin may be used in mild cases, but is not typically the first-line choice.

The First-Line Empiric Antibiotic Choice for Treatment of Community-Acquired Pneumonia