A mutation of Lys₂₂₉ in aldolase leads to a loss of enzyme activity.This is most likely because the A) active site can no longer exclude water. B) active site can no longer include water. C) enzyme can no longer hold the intermediate in the correct orientation for catalysis. D) product will remain bound to the enzyme active site.

Question

Quizplus · Accepted Answer

The mutation leads to a change in one of the amino acids in the active site of the enzyme, which affects the ability of the enzyme to hold the intermediate in the correct orientation for catalysis. As a result, the enzyme loses its activity. The presence or absence of water in the active site is unlikely to be the main issue, and the mutation is not likely to affect the ability of the enzyme to exclude or include water. The product would be expected to be released from the active site after catalysis, regardless of the mutation.

A Mutation of Lys229 in Aldolase Leads to a Loss

A Mutation of Lys₂₂₉ in Aldolase Leads to a Loss