If there were a technique that allowed one to isolate EGFR1 and EGFR2 at discrete steps along their activation pathway,which of the following would be isolated?
A) A dimer in which EGFR2 contains phosphotyrosines but EGFR1 does not.
B) A dimer in which EGFR1 contains phosphotyrosines but EGFR2 does not.
C) A monomer of EGFR1 that contains phosphotyrosines.
D) A monomer of EGFR2 that contains phosphotyrosines.

Question

Quizplus · Accepted Answer

EGFR1 and EGFR2 form a heterodimer upon ligand binding, and EGFR2 is phosphorylated first, followed by EGFR1.

If There Were a Technique That Allowed One to Isolate