Which molecule in the net reaction of the citrate cycle contributes to the inhibition of pyruvate dehydrogenase? A) FAD B) H₂O C) H⁺ D) NADH

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Quizplus · Accepted Answer

NADH, a product of the citrate cycle, contributes to the inhibition of pyruvate dehydrogenase through feedback inhibition. High levels of NADH indicate that the cell has sufficient energy and does not need to produce more through the citrate cycle, which would require pyruvate to be converted to acetyl-CoA by pyruvate dehydrogenase. Therefore, high levels of NADH inhibit pyruvate dehydrogenase, preventing unnecessary energy production.

Which Molecule in the Net Reaction of the Citrate Cycle