The regulatory mechanism in the citrate cycle involving the NADH to NAD⁺ ratio is considered to be an example of regulation by A) pH and protonation state. B) product inhibition. C) covalent modification. D) pH and enzyme conformation.

Question

Quizplus · Accepted Answer

The NADH to NAD+ ratio is a measure of the amount of energy being produced in the cell. The citrate cycle is regulated by feedback inhibition, which occurs when the end product of a pathway inhibits an enzyme earlier in the pathway. In this case, when the NADH to NAD+ ratio is high (indicating high energy production), the citrate cycle is inhibited to prevent excess energy production. This is an example of product inhibition.

The Regulatory Mechanism in the Citrate Cycle Involving the NADH