How is penicillin inactivated by penicillin-resistant bacteria?
A) Transpeptidase binds to methicillin.
B) The carbonyl carbon of the -lactam ring binds to transpeptidase.
C) The -lactam ring in penicillin is hydrolyzed.
D) The serine in transpeptidase binds to penicillin.

Question

How is penicillin inactivated by penicillin-resistant bacteria?
A) Transpeptidase binds to methicillin. 
B) The carbonyl carbon of the -lactam ring binds to transpeptidase. 
C) The -lactam ring in penicillin is hydrolyzed. 
D) The serine in transpeptidase binds to penicillin.

Quizplus · Accepted Answer

Penicillin is inactivated by penicillin-resistant bacteria through hydrolysis of the 11ea8d43_ab9a_ded7_b445_8f398ba5513f_TB6697_11_TB6697_11-lactam ring in penicillin, which is catalyzed by β-lactamase enzymes. This hydrolysis breaks the ring and renders penicillin ineffective in inhibiting the enzyme transpeptidase, which is necessary for bacterial cell wall synthesis.

How Is Penicillin Inactivated by Penicillin-Resistant Bacteria