McArdle disease is due to a deficiency in muscle glycogen phosphorylase activity.The result of this deficiency is an inability to
B) form glucose-1-phosphate during the breakdown of glycogen.
C) store glycogen.

Question

McArdle disease is due to a deficiency in muscle glycogen phosphorylase activity.The result of this deficiency is an inability to
B) form glucose-1-phosphate during the breakdown of glycogen. 
C) store glycogen.

Quizplus · Accepted Answer

McArdle disease is caused by a deficiency in the enzyme muscle glycogen phosphorylase, which is responsible for breaking down glycogen in muscle tissue to release glucose-1-phosphate for energy. Without this enzyme, individuals with McArdle disease are unable to effectively break down glycogen and form glucose-1-phosphate, which can lead to muscle weakness and cramping during exercise. Therefore, choice B (inability to form glucose-1-phosphate during the breakdown of glycogen) is the best answer.

McArdle Disease Is Due to a Deficiency in Muscle Glycogen