Cholesterol biosynthesis and cholesterol uptake is stimulated by

Question

Quizplus · Accepted Answer

Cholesterol biosynthesis and uptake are both stimulated by the binding of sterol regulatory element-binding proteins (SREBPs) to sterol regulatory element (SRE) sequences. This leads to activation of genes necessary for cholesterol biosynthesis or uptake. Increased levels of cholesterol can inhibit the activity of SREBPs, but the main mechanism of regulation is through SREBP binding to SREs. LDL uptake through the LDL receptor can also impact cellular cholesterol levels, but this does not directly stimulate biosynthesis or uptake. Therefore, the best choice is B.

Cholesterol Biosynthesis and Cholesterol Uptake Is Stimulated by