The two mechanisms to regulate protein ubiquitination are biochemical changes to

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The two mechanisms to regulate protein ubiquitination involve biochemical changes to both the target proteins and the E3 ligases. These changes can affect the specificity and efficiency of the ubiquitination reaction, leading to increased or decreased ubiquitination of target proteins. While changes to E2 and E1 ligases can also impact ubiquitination, they are not considered the primary mechanisms of regulation. The E2-ubiquitin-E3 complex is a key component of the ubiquitination process but is not a mechanism of regulation itself.

The Two Mechanisms to Regulate Protein Ubiquitination Are Biochemical Changes