The conversion of adenosine to inosine is catalyzed by __________,which is deficient in __________.
A) HGPRT; Lesch-Nyhan syndrome
B) adenosine deaminase; ADA-SCID
C) xanthine oxidase; Lesch-Nyhan syndrome
D) purine nucleoside phosphorylase; ADA-SCID

Question

Quizplus · Accepted Answer

The conversion of adenosine to inosine is catalyzed by adenosine deaminase, which is deficient in ADA-SCID (adenosine deaminase-deficient severe combined immunodeficiency). Lesch-Nyhan syndrome is caused by the deficiency of the enzyme HGPRT (hypoxanthine-guanine phosphoribosyltransferase) or by a defect in purine salvage pathways, which results in the overproduction of uric acid and neurological symptoms. Xanthine oxidase is involved in the purine degradation pathway and its deficiency leads to xanthinuria, but not to the conversion of adenosine to inosine. Purine nucleoside phosphorylase deficiency results in the accumulation of deoxyguanosine, not in the conversion of adenosine to inosine.

The Conversion of Adenosine to Inosine Is Catalyzed by __________,Which