Dihydropyrimidine dehydrogenase deficiencies can lead to an intolerance of high doses of 5-fluorouracil because 5-fluorouracil __________ dihydropyrimidine dehydrogenase.
A) is usually metabolized by
B) inhibits
C) allosterically activates
D) denatures

Question

Quizplus · Accepted Answer

Dihydropyrimidine dehydrogenase is the enzyme responsible for metabolizing 5-fluorouracil. Deficiencies in this enzyme can lead to an accumulation of the drug, causing toxicity.

Dihydropyrimidine Dehydrogenase Deficiencies Can Lead to an Intolerance of High