Predict the metabolic outcome of a partial inhibition of lipoprotein lipase.
A) Neurons in the brain would no longer use free fatty acids as a fuel source.
B) Rates of glycogen breakdown in heart muscle would increase.
C) Levels of ketone bodies in the blood would decrease.
D) Liver lactate dehydrogenase activity levels would decrease.

Question

Quizplus · Accepted Answer

Lipoprotein lipase breaks down triglycerides into free fatty acids and glycerol, which are used as fuel by many tissues including the brain. Inhibiting lipoprotein lipase would result in a decrease in free fatty acids available for this purpose. However, the liver can produce ketone bodies from fatty acid breakdown, which can also serve as a fuel source. Therefore, a partial inhibition of lipoprotein lipase would lead to a decrease in ketone bodies in the blood.

Predict the Metabolic Outcome of a Partial Inhibition of Lipoprotein