Which of the following sequences is most likely a nuclear localization signal?
A) Lys-Lys-Arg-Gly-Arg
B) Glu-Asp-Asp-Gly-Glu
C) Ile-Leu-Phe-Leu-Gly
D) Lys-Asp-Arg-Glu-Glu

Question

Quizplus · Accepted Answer

The sequence Lys-Lys-Arg-Gly-Arg is a commonly recognized nuclear localization signal (NLS) that directs transport of proteins from the cytoplasm to the nucleus. The positively charged lysine and arginine residues are recognized by importins, which facilitate transport through the nuclear pore complex.

Which of the Following Sequences Is Most Likely a Nuclear