The most likely reason for the development of an IgE antibody response in humans is:

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IgE antibodies play a significant role in protecting humans against helminth infections. They trigger the release of histamines and other mediators that induce spasms in the smooth muscles of helminths, which eventually expel the parasites out of the body. IgE antibodies do not provide protection against bacterial or viral infections. However, IgE antibodies can also bind to allergens, leading to the release of histamines and other mediators that cause symptoms of allergies.

The Most Likely Reason for the Development of an IgE