A disease characterized by hypoactivity of the thyroid with weight gain and a sluggish metabolism due to destruction of thyroglobulin best describes:

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Hashimoto's thyroiditis is an autoimmune disorder in which the body's immune system attacks the thyroid gland, resulting in reduced production of thyroid hormones. This leads to symptoms such as weight gain, sluggish metabolism, and fatigue. Graves' disease, on the other hand, is characterized by hyperactivity of the thyroid gland, resulting in symptoms such as weight loss, increased heart rate, and anxiety. Myasthenia gravis is a neuromuscular disorder that causes muscle weakness and fatigue, while rheumatoid arthritis is an autoimmune disorder that primarily affects the joints. Neither of these conditions are directly related to thyroid function.

A Disease Characterized by Hypoactivity of the Thyroid with Weight