The principle difference between type II and type III hypersensitivity reactions is the:

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The principle difference between type II and type III hypersensitivity reactions is the nature of the antigens involved. In type II hypersensitivity, the antigen is a cell surface or extracellular matrix component, leading to lysis or destruction of the host cell by complement or antibody-dependent cellular cytotoxicity. In type III hypersensitivity, the antigen is a soluble molecule that forms immune complexes with antibodies, which deposit in tissues and activate complement, leading to inflammation and tissue damage. The isotype(s) of antibody involved (A) and the involvement of helper T cells and macrophages (D) are not specific to either type II or type III.

The Principle Difference Between Type II and Type III Hypersensitivity