The alternative and classical pathway C3 convertases are destabilized as a means of down-regulating complement function.One molecule that performs this function is:

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Membrane cofactor protein (MCP) is a cell-surface regulator that specifically down-regulates complement convertases of the alternative and classical pathways. MCP binds to and inactivates C3b, blocking the formation of the C3 convertase and hence preventing the downstream activation of the complement system.

The Alternative and Classical Pathway C3 Convertases Are Destabilized as a Means