A 28-year-old female with cold hemagglutinin disease has a positive DAT. When the DAT is repeated using monospecific reagent, which of the following is most likely to be detected?

Question

Quizplus · Accepted Answer

Cold hemagglutinin disease is an autoimmune hemolytic anemia caused by IgM antibodies that react with the I antigen on red blood cells. The DAT is positive in cold hemagglutinin disease because the IgM antibodies bind to the red blood cells and activate complement. When the DAT is repeated using monospecific reagent, IgM is most likely to be detected because it is the antibody that is responsible for the hemolytic anemia.

A 28-Year-Old Female with Cold Hemagglutinin Disease Has a Positive