How is an febrile nonhemolytic transfusion reaction FNHTR best defined?

Question

Quizplus · Accepted Answer

FNHTR is defined as a 1°C temperature rise or greater during or after a blood transfusion, without any other medical explanation such as infection, and with no evidence of hemolysis (destruction of red blood cells). It is usually caused by a patient's immune system reacting to white blood cells in the transfused blood, which release cytokines and cause a fever and other symptoms of inflammation. Inflammation of the colon or pneumonia is not typically associated with FNHTR.

How Is an Febrile Nonhemolytic Transfusion Reaction FNHTR Best Defined