An immediate spin crossmatch was performed using recipient serum and donor cells from a group AB unit. At immediate spin, the reaction was 4+. What is the reason for this positive reaction?

Question

Quizplus · Accepted Answer

A 4+ reaction at immediate spin suggests that there is an ABO incompatibility between the recipient and the donor unit. This means that the donor unit contains A or B antigens that the recipient does not have, leading to the formation of anti-A or anti-B antibodies in the recipient's serum, which react with the donor cells at immediate spin. The other options are less likely since they would lead to positive reactions at other phases of testing, such as the antiglobulin phase.

An Immediate Spin Crossmatch Was Performed Using Recipient Serum and Donor