A type-A person demonstrates a 3+ reactivity with A₁ cells (reverse grouping). The forward grouping with anti-A is 4+. Therefore, the possibility of a subgroup is excluded. B cells demonstrate a 4+ reaction. The antibody screen is weakly positive at 37°C but shows no reactivity at the AHG phase. An antibody panel is performed and anti-M is identified. The patient phenotypes negative for M antigen. How is the ABO discrepancy resolved?

Question

Quizplus · Accepted Answer

The discrepancy is due to the presence of anti-M, which reacts at room temperature. Using A1 cells negative for M antigen in reverse grouping will resolve the discrepancy.

A Type-A Person Demonstrates a 3+ Reactivity with A1 Cells

A Type-A Person Demonstrates a 3+ Reactivity with A₁ Cells