HLA specificities were first defined in the laboratory based on which type of methodology?

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HLA specificities were first defined using serological methods, which involve testing for the presence or absence of antibodies that react with HLA molecules. The antibodies used in these tests are produced by immunizing animals with human lymphocytes or HLA molecules and then testing the serum for reactivity with HLA molecules in cell-based assays or on bead-based systems.

HLA Specificities Were First Defined in the Laboratory Based on Which