Ten equivalents of a genome were cut into small pieces and sequenced. Computers were then used to put the sequences of the pieces together to determine the sequence of the intact genome. The method described is which of the following?

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Quizplus · Accepted Answer

This method is known as Whole Genome Shotgun Sequencing, in which the genome is randomly cut into small pieces and sequenced. Later, the sequences of these pieces are put together using overlapping regions to determine the sequence of the intact genome. This method is commonly used in modern genome sequencing projects. Option A is a program used to compare DNA or protein sequences with a library of sequences, Option B does not describe this method accurately, and Option D is not a widely used term for genome sequencing methods.

Ten Equivalents of a Genome Were Cut into Small Pieces