A reference segment of DNA has the following sequence: GCTCACCATGG. Insertion of AG occurs between positions 7 and 8 in a particular genetic disease. How is this mutation denoted by accepted nomenclature?

Question

Quizplus · Accepted Answer

The insertion of AG occurs between positions 7 and 8 in the reference sequence GCTCACCATGG. The insertion is denoted using the nomenclature format of x_yinsZ, where x and y are the positions of the insertion site, and Z is the nucleotide sequence that is inserted. Therefore, the correct nomenclature for the mutation is 7_8insAG.

A Reference Segment of DNA Has the Following Sequence: GCTCACCATGG