This test is used to determine if the mismatch repair system is functioning normally.

Question

Quizplus · Accepted Answer

Microsatellite instability is a hallmark of mismatch repair deficiency, which can occur in hereditary non-polyposis colon cancer (HNPCC). This test involves analyzing short tandem repeat sequences in DNA, and if there are errors in the number of repeats, it indicates a defect in the mismatch repair system. Translocation of DNA between chromosomes (A) is not specifically related to the mismatch repair system, and clonality of immunoglobulin gene rearrangements (C) and overexpression of Her2/neu (D) are used to diagnose certain types of cancer but not related to the mismatch repair system.

This Test Is Used to Determine If the Mismatch Repair