What genes are most likely mutated in inherited colon cancer with microsatellite instability?

Question

Quizplus · Accepted Answer

In inherited colon cancer with microsatellite instability, mutations are most likely to occur in genes involved in DNA repair, such as MLH1 and MSH2. FLT3 and NPM are commonly associated with acute myeloid leukemia, BRCA1 and BRCA2 are associated with inherited breast and ovarian cancer, and RET and n-myc are associated with different types of neuroendocrine tumors.

What Genes Are Most Likely Mutated in Inherited Colon Cancer