How is hereditary erythroblastic multinuclearity with positive acidified serum (HEMPAS) test differentiated from PNH patients in the Ham's test?

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Quizplus · Accepted Answer

In HEMPAS, RBCs are not lysed by the patient's own acidified serum, whereas in PNH, RBCs are lysed due to deficiency in complement regulatory proteins. Therefore, the Ham's test, which uses acidified serum to lyse RBCs, will differentiate these two conditions based on the ability of the patient's serum to cause hemolysis. The other options are not relevant for distinguishing between HEMPAS and PNH in the Ham's test.

How Is Hereditary Erythroblastic Multinuclearity with Positive Acidified Serum (HEMPAS)