A doctor is concerned about the possibility of aPL syndrome in her patient, who had a stroke when she was 23 years old. Which of the following lab results is consistent with aPL syndrome?

Question

Quizplus · Accepted Answer

The lab results consistent with aPL syndrome are a prolonged APTT with correction on addition of excess phospholipid, prolonged APTT on mixing study, normal dRVTT, and normal dPT. These results are present on repeat testing, as in option C. Option A has a prolonged APTT but corrects with mixing studies and has a normal dRVVT. Option B has a high aCL titer once but normal 6 weeks later, and normal APTT, dRVVT, and PT. Option D has a prolonged PT and APTT, but they correct with mixing studies. Option E has normal APTT and dRVVT, but a prolonged dPT that remains prolonged with the addition of excess phospholipid, which is not consistent with aPL syndrome.

A Doctor Is Concerned About the Possibility of APL Syndrome