vWD is an autosomal dominant disorder characterized by decreased or absent __________ and a decrease in factor __________ secondary to the primary defect in vWF.

Question

Quizplus · Accepted Answer

vWD stands for von Willebrand disease, which is caused by a deficiency or dysfunction of von Willebrand factor (vWF). vWF plays a key role in blood coagulation by mediating platelet adhesion and promoting blood clotting factor VIII:C (Factor VIII) stabilization. Therefore, the primary defect in vWF causes a decrease in Factor VIII:C levels, explaining the answer choice C. Answer choices A and D are incorrect because Factor IX is not directly affected in vWD. Answer choice B is incorrect because while Factor VIII:C levels are decreased in vWD, it is not the primary defect. Answer choice E is also incorrect because an answer choice is required.

VWD Is an Autosomal Dominant Disorder Characterized by Decreased or Absent