In variant vWD, identification is essential for proper treatment. This can be accomplished by:

Question

Quizplus · Accepted Answer

Variant von Willebrand Disease (vWD) diagnosis involves a combination of tests because it affects the vWF protein in different ways. Ristocetin-induced platelet aggregation studies assess how well the vWF mediates platelet adhesion. Multimeric analysis evaluates the structure and size distribution of vWF multimers, which is crucial for understanding the specific type of vWD. Testing for Factor VIII:C, Factor VIII:R Co, and vWF:Ag levels helps in assessing the quantity and functionality of vWF and its interaction with Factor VIII. Together, these tests provide a comprehensive approach for the identification and classification of variant vWD, which is essential for determining the most appropriate treatment strategy.

In Variant VWD, Identification Is Essential for Proper Treatment