In Tay-Sachs disease, there is an accumulation of unmetabolized __________, which has devastating effects on the central nervous system and eyes.

Question

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In Tay-Sachs disease, there is an accumulation of unmetabolized ganglioside GM2, specifically GM₂ ganglioside, due to a deficiency in hexosaminidase A. This accumulation leads to the destruction of nerve cells in the central nervous system and eyes, resulting in severe neurological symptoms and eventually death in early childhood.

In Tay-Sachs Disease, There Is an Accumulation of Unmetabolized __________