CML can be differentiated from polycythemia vera, essential thrombocythemia, and agnogenic myeloid metaplasia by the presence of __________.

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The presence of the Philadelphia (Ph) chromosome, a genetic abnormality involving the fusion of the BCR and ABL genes, is a hallmark diagnostic feature of chronic myeloid leukemia (CML). It is not present in polycythemia vera (D), essential thrombocythemia (E), or agnogenic myeloid metaplasia. While splenomegaly (C) is common in CML, it is not specific to the disease, as it can also be found in other myeloproliferative neoplasms. Leukocytosis (A) and erythrocytosis (D) can occur in CML, but they are not distinguishing features. Thrombocytosis (E) is more characteristic of essential thrombocythemia than CML.

CML Can Be Differentiated from Polycythemia Vera, Essential Thrombocythemia, and Agnogenic