A 49-year-old woman was admitted to the hospital for easy bruising and menorrhagia. She had evidence of disseminated intravascular coagulation. Her white blood cell count is 3 $\times$ 10⁹/L with 95% large, atypical mononuclear cells and some atypical bilobed cells. Many of these cells are packed with larger, purple-staining granules; some have multiple Auer rods; and all are strongly peroxidase-positive. What is the diagnosis?

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Quizplus · Accepted Answer

The patient's presentation is consistent with acute promyelocytic leukemia (APL), which is classified as AML, FAB M3. The presence of atypical mononuclear cells with multiple Auer rods and larger, purple-staining granules is characteristic of APL. Additionally, the patient's clinical symptoms of easy bruising and menorrhagia are common in APL due to the coagulation abnormalities associated with this subtype of AML.

A 49-Year-Old Woman Was Admitted to the Hospital for Easy ×\times×

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