In anemia associated with renal disease, the anemia that develops is the result of inadequate quantity of circulating:

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Anemia associated with renal disease is commonly due to a lack of erythropoietin (EPO) production by the kidneys. EPO is a hormone that regulates the production of red blood cells in the bone marrow. In renal disease, the kidneys are unable to produce sufficient EPO, leading to a decrease in red blood cell production and anemia. Thrombopoietin, interleukin (IL-1), G-CSF, and GM-CSF are not related to the development of anemia in renal disease.

In Anemia Associated with Renal Disease, the Anemia That Develops