In two-thirds of cases of warm autoimmune hemolytic anemia (WAIHA), the direct antiglobulin test (DAT) will result in reactivity with:

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In approximately two-thirds of cases of warm autoimmune hemolytic anemia (WAIHA), the direct antiglobulin test (DAT) will result in reactivity with both IgG and C3d. This indicates a presence of both complement and antibody coating the red blood cells, leading to their destruction by phagocytic cells in the spleen and liver. IgG alone may also be present in some cases, but the addition of C3d increases the severity of hemolysis. C3d alone is rare and usually only seen in cases of complement-mediated hemolysis. IgA and IgE are not typically involved in the pathogenesis of warm autoimmune hemolytic anemia.

In Two-Thirds of Cases of Warm Autoimmune Hemolytic Anemia (WAIHA)