At the molecular level, which is the most common cause of a hemoglobinopathy?

Question

Quizplus · Accepted Answer

The most common cause of a hemoglobinopathy is a single-base DNA substitution, which leads to a change in the corresponding triplet codon and the production of abnormal hemoglobin. This is the case with sickle cell anemia, the most well-known hemoglobinopathy. Multiple-base substitutions, the production of long or short subunits, and the occurrence of fusion subunits are much less common causes.

At the Molecular Level, Which Is the Most Common Cause