Multiple infarctions and subsequent fibrosis of the spleen lead to what process in adult patients with sickle cell anemia?

Question

Quizplus · Accepted Answer

Multiple infarctions and subsequent fibrosis of the spleen can lead to complete loss of splenic function and eventual autosplenectomy in adult patients with sickle cell anemia. Splenomegaly and hepatosplenomegaly may occur earlier in the disease process, but they are not the final outcome. Extramedullary hematopoiesis may occur as a compensatory mechanism in response to loss of splenic function, but it is not directly related to the process of multiple infarctions and fibrosis. Therefore, the only correct answer is C.

Multiple Infarctions and Subsequent Fibrosis of the Spleen Lead to What