What Does (HE) (4.1) Denote

What does (HE) (4.1) denote?

A) Hereditary spherocytosis with the absence of spectrin
B) Hereditary elliptocytosis with the absence of protein 4.1
C) Hereditary elliptocytosis with the absence of spectrin
D) Hereditary elliptocytosis with a partial deficiency of protein 4.1
E) None of the above