The abnormal red cell membrane in PNH is highly sensitive to:

Question

Quizplus · Accepted Answer

The abnormal red cell membrane in PNH is highly sensitive to complement, leading to intravascular hemolysis. This is due to the absence of complement regulatory proteins, such as CD55 and CD59, on the surface of affected cells. This makes PNH patients susceptible to a wide range of symptoms, including hemolytic anemia, thrombosis, and renal failure. Alloantibodies, drug-induced antibodies, and IL-1 do not play a significant role in the pathology of PNH.

The Abnormal Red Cell Membrane in PNH Is Highly Sensitive