Platelets from patients with these two disorders will not aggregate with ristocetin.

Question

Quizplus · Accepted Answer

Ristocetin-induced platelet aggregation requires von Willebrand factor and the glycoprotein Ib receptor. In von Willebrand's disease, there is a deficiency or dysfunction of von Willebrand factor, and in Bernard-Soulier syndrome, there is a defect in the glycoprotein Ib receptor, both leading to impaired aggregation with ristocetin.

Platelets from Patients with These Two Disorders Will Not Aggregate