Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:

Name: Cholelithiasis is a frequent complication of patients with hereditary spherocytosis because:
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In hereditary spherocytosis, there is a chronic hemolysis of red blood cells. The breakdown of the hemoglobin leads to an increase in unconjugated bilirubin, which is excreted into bile. Over time, the increased concentration of bilirubin in the bile can lead to the formation of gallstones (cholelithiasis).

Cholelithiasis Is a Frequent Complication of Patients with Hereditary Spherocytosis