In regards to the thalassemias, the deficit has nothing to do with iron.

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Thalassemias are a group of inherited blood disorders that affect the production of hemoglobin, which is the protein in red blood cells that carries oxygen. The deficit in thalassemias is related to a decrease in or defect in the production of one or more of the globin chains that make up hemoglobin, and is not related to iron levels. However, individuals with thalassemia may require iron chelation therapy to manage excess iron from blood transfusions, which may be needed to treat severe forms of the disorder.

In Regards to the Thalassemias, the Deficit Has Nothing to Do