Individuals with Down syndrome and with Alzheimer's disease often share a common characteristic,the presence of abnormal forms of the amyloid protein.

Question

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Individuals with Down syndrome have an extra copy of chromosome 21, which contains the gene for amyloid precursor protein (APP) leading to an overproduction of amyloid beta protein, which is also a key player in the development of Alzheimer's disease. Therefore individuals with Down syndrome are at high risk of developing Alzheimer's disease.

Individuals with Down Syndrome and with Alzheimer's Disease Often Share