Olney's concept of excitotoxicity suggests that most neural death in ischemia is due to
A) excess cholinergic activity.
B) insufficient GABA activity.
C) insufficient glutamate activity.
D) excess glutamate activity.

Question

Quizplus · Accepted Answer

Olney's concept of excitotoxicity suggests that most neural death in ischemia is due to excessive release of glutamate, an excitatory neurotransmitter, and subsequent overactivation of glutamate receptors in neurons, leading to cellular damage and death.

Olney's Concept of Excitotoxicity Suggests That Most Neural Death in Ischemia