One likely candidate for a "headache generator" is the
A) locus coeruleus.
B) substantia nigra.
C) raphe nuclei.
D) periaqueductal gray.

Question

Quizplus · Accepted Answer

The raphe nuclei, located in the brainstem, are involved in the modulation of pain sensation and are known to contain high concentrations of serotonin. Dysregulation of the serotonin system in the raphe nuclei has been implicated in the development of headaches, including migraines. Therefore, the raphe nuclei are a likely candidate for a "headache generator." The other structures listed (locus coeruleus, substantia nigra, and periaqueductal gray) are not as strongly associated with the development of headaches.

One Likely Candidate for a "Headache Generator" Is the