Relative to Healthy Controls,people with Major Depressive Disorder

Relative to healthy controls,people with major depressive disorder 

A) show no differences in brain structure or activity. 
B) show increased volume in the hippocampus and orbitofrontal cortex. 
C) show decreased volume in the hippocampus and orbitofrontal cortex. 
D) show decreased volume in the hippocampus, but increased volume in the orbitofrontal cortex.