The highest level of evidence to support interventions at the end of life is with:

Question

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The highest level of evidence to support interventions at the end of life is with opioids for dyspnea (difficulty breathing), which is a common and distressing symptom at the end of life. Opioids have been shown to effectively relieve dyspnea in multiple randomized controlled trials and are recommended as the first-line treatment for this symptom by several clinical guidelines. While hyoscine and stimulant laxatives may also be used in end-of-life care, there is less evidence to support their use compared to opioids for dyspnea.

The Highest Level of Evidence to Support Interventions at the End