Amyloid plaques and neurofibrillary tangles are two of the main characteristics of what disease?

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Amyloid plaques and neurofibrillary tangles are two of the main pathological features of Alzheimer's disease, a devastating neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and behavioral changes. Amyloid plaques are formed by the accumulation of beta-amyloid protein, which is toxic to neurons, while neurofibrillary tangles occur when hyperphosphorylated tau proteins aggregate and disrupt the structural integrity of neurons. These abnormalities ultimately lead to neuronal death, brain atrophy, and functional impairments in affected individuals.

Amyloid Plaques and Neurofibrillary Tangles Are Two of the Main